Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field

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dc.creator Rico, María José
dc.creator Perroud, Herman A
dc.creator Mainetti, Leandro Ernesto
dc.creator Rozados, Viviana R.
dc.creator Scharovsky, O. Graciela
dc.date.accessioned 2018-04-19T17:01:01Z
dc.date.available 2018-04-19T17:01:01Z
dc.date.issued 2014-02-05
dc.identifier.issn 0735-7907 es
dc.identifier.uri http://hdl.handle.net/2133/11113
dc.description Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic. es
dc.description.sponsorship Universidad Nacional de Rosario es
dc.format application/pdf
dc.format.extent 92-98 es
dc.language.iso eng es
dc.publisher Taylor & Francis es
dc.rights openAccess es
dc.subject Metronomic chemotherapy es
dc.subject Combined treatment es
dc.subject Cyclophosphamide es
dc.subject Doxorubicin es
dc.subject Celecoxib es
dc.subject  Mammary adenocarcinomas es
dc.title Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field es
dc.type article
dc.type artículo
dc.type acceptedVersion
dc.rights.holder Autores es
dc.rights.holder Taylor & Francis es
dc.relation.publisherversion https://doi.org/10.3109/07357907.2013.877480 es
dc.citation.title Cancer Investigation es
dc.citation.volume 32 es
dc.description.fil Fil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina es
dc.description.fil Fil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina es
dc.description.fil Fil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentina es
dc.description.fil Fil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina es
dc.description.fil Fil: Scharovsky, Graciela Olga. Universidad Nacional de Rosario. Consejo de Investigaciones UNR, Facultad de Ciencias Médicas; Argentina es
dc.type.collection articulo
dc.type.version acceptedVersion es


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