Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters

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dc.creator	Lozano, Valeria Antonella
dc.creator	Escandar, Graciela Mónica
dc.date.accessioned	2019-02-08T20:39:00Z
dc.date.available	2019-02-08T20:39:00Z
dc.date.issued	2013-06-11
dc.identifier.issn	0003-2670
dc.identifier.uri	http://hdl.handle.net/2133/13922
dc.description	A photochemically induced fluorescence system combined with second-order chemometric analysis for the determination of the anticonvulsant carbamazepine (CBZ) is presented. CBZ is a widely used drug for the treatment of epilepsy and is included in the group of emerging contaminant present in the aquatic environment. CBZ is not fluorescent in solution but can be converted into a fluorescent compound through a photochemical reaction in a strong acid medium. The determination is carried out by measuring excitation–emission photoinduced fluorescence matrices of the products formed upon ultraviolet light irradiation in a laboratory-constructed reactor constituted by two simple 4 W germicidal tubes. Working conditions related to both the reaction medium and the photoreactor geometry are optimized by an experimental design. The developed approach enabled the determination of CBZ at trace levels without the necessity of applying separation steps, and in the presence of uncalibrated interferences which also display photoinduced fluorescence and may be potentially present in the investigated samples. Different second-order algorithms were tested and successful resolution was achieved using multivariate curve resolution-alternating least-squares (MCR-ALS). The study is employed for the discussion of the scopes and yields of each of the applied second-order chemometric tools. The quality of the proposed method is probed through the determination of the studied emerging pollutant in both environmental and drinking water samples. After a pre-concentration step on a C18 membrane using 50.0 mL of real water samples, a prediction relative error of 2% and limits of detection and quantification of 0.2 and 0.6 ng mL−1 were respectively obtained.	es
dc.description.sponsorship	Universidad Nacional de Rosario (Argentina)	es
dc.description.sponsorship	Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): Proyecto PIP 1950	es
dc.format	application/pdf
dc.format.extent	37-45
dc.language.iso	eng	es
dc.publisher	Elsevier	es
dc.rights	openAccess	es
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es	*
dc.subject	Photoinduced fluorescence	es
dc.subject	Multivariate calibration	es
dc.subject	Carbamazepine	es
dc.title	Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters	es
dc.rights.holder	Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas	es
dc.rights.holder	Lozano, Valeria Antonella	es
dc.rights.holder	Escandar, Graciela Mónica	es
dc.rights.holder	Elsevier	es
dc.relation.publisherversion	https://dx.doi.org/10.1016/j.aca.2013.04.020	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S000326701300531X?via%3Dihub#ack0005	es
dc.rights.text	Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)	es
dc.citation.title	Analytica Chimica Acta	en
dc.citation.volume	782
dc.description.fil	Fil: Lozano, Valeria Antonella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina	es
dc.description.fil	Fil: Escandar, Graciela Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.	es