• Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models 

  Giolito, Maria Virginia; Camacho, Cristian M.; Martinez-Amezaga, Maitena; Traficante, Carla Inés; Giordano, Rocío A.; Cornier, Patricia G.; Mata, Ernesto G.; Delpiccolo, Carina M.L.; Boggián, Dora G.; Del Giúdice, Antonela; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; Rozados, Viviana R.; Rico, María José (Future Science Group, 2020-01-23)
• Achievements and challenges in the use of metronomics for the treatment of breast cancer 

  Scharovsky, O. Graciela; Rico, María José; Mainetti, Leandro Ernesto; Perroud, Herman A; Rozados, Viviana R. (Elsevier, 2020-03)
• Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer 

  Perroud, Herman A; Rico, María José; Alasino, Carlos María; Pezzotto, Stella Maris; Rozados, Viviana R.; Scharovsky, O. Graciela (Indian Cancer Society and Indian Society of Oncology, 2013-08-27)
• Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models 

  Rico, María José; Baglioni, María; Bondarenko, Maryna; Laluce, Nahuel Cesatti; Rozados, Viviana R.; André, Nicolas; Carré, Manon; Scharovsky, O. Graciela; Márquez, Mauricio Menacho (Rapamycin Press, 2016-12-01)
• Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients 

  Perroud, Herman A; Rico, María José; Alasino, Carlos María; Queralt, Francisco ; Mainetti, Leandro Ernesto; Pezzotto, Stella Maris; Rozados, Viviana R.; Scharovsky, O. Graciela (Future Medicine Ltd, 2013-03-08)
• Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response 

  Perroud, Herman A; Alasino, Carlos María ; Rico, María José; Mainetti, Leandro Ernesto; Queralt, Francisco ; Pezzotto, Stella Maris; Rozados, Viviana R.; Scharovsky, O. Graciela (Springer, 2016-02)
• Differential production of angiostatin by concomitant antitumoral resistance-inducing cancer cells 

  Binda, María Mercedes; Matar, Pablo; González, Alejandro D.; Rozados, Viviana R.; Gervasoni, Silvia I.; Scharovsky, O. Graciela; Bonfil, R. Daniel (Wiley, 2002-05-02)

  The phenomenon by which tumor-bearing hosts are capable of inhibiting secondary tumor implants or metastases, known as concomitant antitumoral resistance (CAR), is presumably due to antiangiogenesis at places distant from ...
• Modulation of IL-10/IL-10R expression by mafosfamide, a derivative of 4-hydroxycyclophosphamide, in a rat B-cell lymphoma 

  Rico, María José; Matar, Pablo; Scharovsky, O. Graciela (Sociedad Latinoamericana de Microscopía Electrónica. Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina), 2012-08)

  We have already shown that IL-10 plays an important role in immunosuppression and metastatic dissemination in the rat B-cell lymphoma L-TACB model. It was suggested that the up-regulation of IL-10 production and IL-10 ...
• Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models 

  Rozados, Viviana R.; Hinrichsen, Lucila Isabel; Binda, María Mercedes; Gervasoni, Silvia I.; Matar, Pablo; Bonfil, Daniel R.; Scharovsky, O. Graciela (Spandidos (Grecia), 2008-05)

  Despite its effectiveness as an antineoplastic drug, doxorubicin (DOX) is usually associated with cardiotoxicity. Lovastatin (LOV), a hypolipidemic agent used in the clinic, has been demonstrated to have antitumoral and ...
• Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity 

  Rozados, Viviana R.; Sánchez, Andrea M.; Gervasoni, Silvia I.; Berra, Héctor H.; Matar, Pablo; Scharovsky, O. Graciela (Oxford University Press, 2004-10)

  BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged ...
• Terapia génica: el desafío terapéutico del siglo XXI 

  Scharovsky, O. Graciela (Círculo Médico de Rosario (Argentina), 2001-07)

  La terapia génica es una forma de medicina molecular que probablemente tendrá un gran impacto en la salud humana a lo largo del siglo XXI. Tiene como objetivo modificar o reparar una alteración genética adquirida, corregir ...
• The Immune Response and the Therapeutic Effect of Metronomic Chemotherapy With Cyclophosphamide 

  Rozados, Viviana R.; Mainetti, Leandro Ernesto; Rico, María José; Zacarías Fluck, Mariano; Matar, Pablo; Scharovsky, O. Graciela (Cognizant Communication Corporation, 2010-11-01)

  Metronomic chemotherapy (MCT) is a novel therapeutic strategy for cancer treatment endowed with an antiangiogenic effect. It refers to regular administration of low doses of cytotoxic drugs, with minimal or no drug-free ...
• A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice 

  Malvicini, Mariana; Rizzo, Miguel; Alaniz, Laura; Piñero, Federico; García, Mariana; Atorrasagasti, Catalina; Aquino, Jorge B.; Rozados, Viviana R.; Scharovsky, O. Graciela; Matar, Pablo; Mazzolini, Guillermo (American Association for Cancer Research, 2009-11)

  PURPOSE: Interleukin-12 (IL-12) is an immunostimulatory cytokine with potent antitumor effects in several animal models. However, serious toxicity has been associated with its systemic application in humans. Gene transfer ...
• Metronomic chemotherapy: changing the paradigm that more is better 

  Scharovsky, O. Graciela; Mainetti, Leandro Ernesto; Rozados, Viviana R. (Multimed Inc., 2009-03)

  The introduction of the “maximum tolerated dose” in usual treatment protocols (and its concomitant overt toxicity) made necessary the imposition of rest periods between cycles of therapy—a practice that not only involves ...
• Inmunomodulación y antiangiogénesis en la terapéutica oncológica. De la investigación básica a la clínica 

  Scharovsky, O. Graciela; Matar, Pablo; Rozados, Viviana R.; Rico, María José; Zacarías Fluck, Mariano; Mainetti, Leandro Ernesto; Fernández Zenobi, María Virginia (Fundación Revista Medicina (Buenos Aires), 2012-02)

  La investigación básica y pre-clínica en oncología celular y molecular son pilares fundamentales en los que se apoyan la mayoría de los adelantos en la terapéutica del cáncer. Los hallazgos obtenidos y su aplicación en la ...
• Regulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-model 

  Rico, María José; Rozados, Viviana R.; Mainetti, Leandro Ernesto; Zacarías Fluck, Mariano; Matar, Pablo; Scharovsky, O. Graciela (MORION LLC, 2012-03)

  Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by ...
• Paradoxical antiproliferative effect by a murine mammary tumor-derived epithelial cell line 

  Gurzov, Esteban N.; Nabha, Sanaa M.; Yamamoto, Hamilto; Meng, Hong; Scharovsky, O. Graciela; Bonfil, R. Daniel (BioMed Central, 2007-10-01)

  Background Despite significant advancement in breast cancer therapy, there is a great need for a better understanding of the mechanisms involved in breast carcinogenesis and progression, as well as of the role of epigenetic ...
• De la inmunovigilancia al escape tumoral: Historia de un enemigo con múltiples estrategias de resistencia y contra-ataque 

  Scharovsky, O. Graciela; Matar, Pablo; Zacarías Fluck, Mariano; Rico, María José; Rabinovich, Gabriel A. (Sociedad Española de Inmunología, 2006-04)

  Tumors must circumvent the immune response of the host to become clinically detectable. For this purpose, malignant cells have devised multiple strategies to thwart immune attack. These mechanisms are suggested to ...
• Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells 

  Rozados, Viviana R.; Hinrichsen, Lucila Isabel; McDonnel, José; Scharovsky, O. Graciela (BioMed Central; "Regina Elena" National Cancer Institute, Italy, 1905-06-27)

  Our previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, ...
• Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin 

  Ciocca, Daniel R.; Rozados, Viviana R.; Cuello Carrión, F. Darío; Gervasoni, Silvia I.; Matar, Pablo; Scharovsky, O. Graciela (Springer, 2003-01)

  Heat shock protein 27 (Hsp27) and Hsp70 have been involved in resistance to anticancer drugs in human breast cancer cells growing in vitro and in vivo. In this study, we examined the expression of Hsp25 (the rodent homologue ...

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