Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity

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dc.creator Rodríguez Ayala, Facundo
dc.creator Bauman, Carlos
dc.creator Cogliati, Sebastián
dc.creator Leñini, Cecilia
dc.creator Bartolini, Marco
dc.creator Grau, Roberto Ricardo
dc.date.accessioned 2021-03-11T19:28:42Z
dc.date.available 2021-03-11T19:28:42Z
dc.date.issued 2017-03-16
dc.identifier.issn 2311-2638
dc.identifier.uri http://hdl.handle.net/2133/20128
dc.description Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming pro biotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity. We found that biofilm-proficient B. subtilis colonized the C. elegans gut and extended the worm lifespan significantly longer than did biofilm-deficient isogenic strains. In addition to biofilm proficiency, the quorum-sensing pentapeptide CSF and nitric oxide (NO) represent the entire B. subtilis rep ertoire responsible for the extended longevity of C. ele gans. B. subtilis grown under biofilm-supporting condi tions synthesized higher levels of NO and CSF than under planktonic growth conditions, emphasizing the key role of the biofilm in slowing host aging. Significantly, the pro longevity effect of B. subtilis was primarily due to a downregulation of the insulin-like signaling system that precisely is a key partaker in the healthy longevity of hu man centenarians. These findings open the possibility to test if the regular consumption of B. subtilis incorporated in foods and beverages could significantly extend human life expectancy and contribute to stop the development of age-related diseases. es
dc.description.sponsorship Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) es
dc.description.sponsorship Fondo para la Investigación Científica y Tecnológica (FONCYT) es
dc.description.sponsorship Pew Latin-American Program in Biological Sciences es
dc.description.sponsorship Fulbright Committee es
dc.description.sponsorship Fundación Antorchas es
dc.format application/pdf
dc.format.extent 133-136
dc.language.iso eng es
dc.publisher Shared Science Publishers es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ *
dc.subject Bacillus subtilis es
dc.subject Probiotics es
dc.subject Biofilms es
dc.subject Healthy Longevity es
dc.subject Diet Therapy es
dc.subject Insulin Signaling es
dc.title Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity es
dc.type publishedVersion
dc.rights.holder Universidad Nacional de Rosario es
dc.rights.holder Rodríguez Ayala, Facundo es
dc.rights.holder Bauman, Carlos es
dc.rights.holder Cogliati, Sebastián es
dc.rights.holder Leñini, Cecilia es
dc.rights.holder Bartolini, Marco es
dc.rights.holder Grau, Roberto Ricardo es
dc.relation.publisherversion https://doi.org/10.15698/mic2017.04.569 es
dc.relation.publisherversion http://microbialcell.com/researcharticles/microbial-flora-probiotics-bacillus-subtilis-and-the-search-for-a-long-and-healthy-human-longevity/ es
dc.rights.text Attribution 4.0 International (CC BY 4.0) es
dc.citation.title Microbial Cell
dc.citation.title 4(4)
dc.description.fil Fil: Rodríguez Ayala, Facundo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Rodríguez Ayala, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Bauman, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Bauman, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Cogliati, Sebastián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Cogliati, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Leñini, Cecilia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Leñini, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Bartolini, Marco. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Bartolini, Marco. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Grau, Roberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.


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