The stress-responsive alternative sigma factor SigB of Bacillus subtilis and its relatives: an old friend with new functions

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dc.creator Rodríguez Ayala, Facundo
dc.creator Bartolini, Marco
dc.creator Grau, Roberto Ricardo
dc.date.accessioned 2021-04-14T00:52:03Z
dc.date.available 2021-04-14T00:52:03Z
dc.date.issued 2020-09-15
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/2133/20495
dc.description Alternative sigma factors have led the core RNA polymerase (RNAP) to recognize different sets of promoters to those recognized by the housekeeping sigma A-directed RNAP. This change in RNAP promoter selectivity allows a rapid and flexible reformulation of the genetic program to face environmental and metabolic stimuli that could compromise bacterial fitness. The model bacterium Bacillus subtilis constitutes a matchless living system in the study of the role of alternative sigma factors in gene regulation and physiology. SigB from B. subtilis was the first alternative sigma factor described in bacteria. Studies of SigB during the last 40 years have shown that it controls a genetic universe of more than 150 genes playing crucial roles in stress response, adaption, and survival. Activation of SigB relies on three separate pathways that specifically respond to energy, environmental, and low temperature stresses. SigB homologs, present in other Gram-positive bacteria, also play important roles in virulence against mammals. Interestingly, during recent years, other unexpected B. subtilis responses were found to be controlled by SigB. In particular, SigB controls the efficiencies of spore and biofilm formation, two important features that play critical roles in adaptation and survival in planktonic and sessile B. subtilis communities. In B. subtilis, SigB induces the expression of the Spo0E aspartyl-phosphatase, which is responsible for the blockage of sporulation initiation. The upregulated activity of Spo0E connects the two predominant adaptive pathways (i.e., sporulation and stress response) present in B. subtilis. In addition, the RsbP serine-phosphatase, belonging to the energy stress arm of the SigB regulatory cascade, controls the expression of the key transcription factor SinR to decide whether cells residing in the biofilm remain in and maintain biofilm growth or scape to colonize new niches through biofilm dispersal. SigB also intervenes in the recognition of and response to surrounding microorganisms, a new SigB role that could have an agronomic impact. SigB is induced when B. subtilis is confronted with phytopathogenic fungi (e.g., Fusarium verticillioides) and halts fungal growth to the benefit of plant growth. In this article, we update and review literature on the different regulatory networks that control the activation of SigB and the new roles that have been described the recent years. es
dc.description Para citar este articulo: Rodriguez Ayala F, Bartolini M and Grau R (2020) The Stress-Responsive Alternative Sigma Factor SigB of Bacillus subtilis and Its Relatives: An Old Friend With New Functions. Front. Microbiol. 11:1761. doi: 10.3389/fmicb.2020.01761
dc.description.sponsorship Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) es
dc.description.sponsorship Fondo para la Investigación Científica y Tecnológica (FONCYT) es
dc.description.sponsorship Pew Latin American Program in Biomedical Sciences es
dc.description.sponsorship Fulbright Committee es
dc.description.sponsorship Fundación Antorchas es
dc.format application/pdf
dc.format.extent 1-20
dc.language.iso eng es
dc.publisher Frontiers Media es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ *
dc.subject Bacillus subtilis es
dc.subject Alternative Sigma Factors es
dc.subject SigB es
dc.subject General Stress Response es
dc.subject Biofilms es
dc.subject Biocontrol es
dc.subject Sporulation es
dc.title The stress-responsive alternative sigma factor SigB of Bacillus subtilis and its relatives: an old friend with new functions es
dc.type publishedVersion
dc.rights.holder Rodríguez Ayala, Facundo es
dc.rights.holder Bartolini, Marco es
dc.rights.holder Grau, Roberto Ricardo es
dc.rights.holder Universidad Nacional de Rosario
dc.relation.publisherversion https://doi.org/10.3389/fmicb.2020.01761 es
dc.relation.publisherversion https://www.frontiersin.org/articles/10.3389/fmicb.2020.01761/full es
dc.rights.text Attribution 4.0 International (CC BY 4.0) es
dc.citation.title Frontiers in Microbiology
dc.citation.volume 11
dc.description.fil Fil: Rodríguez Ayala, Facundo. Comisión Nacional de Energía Atómica (CNEA). Departamento de Micro y Nanotecnología, Instituto de Nanociencia y Nanotecnología; Argentina.
dc.description.fil Fil: Rodríguez Ayala, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Bartolini, Marco. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Bartolini, Marco. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Grau, Roberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.fil Fil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.


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