Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools

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dc.creator Poppi, Ronei Jesus
dc.creator Sabin, Guilherme Post
dc.creator Lozano, Valeria Antonella
dc.creator Fortunato de Carvalho Rocha, Werickson
dc.creator Ortiz, Rafael
dc.creator Romão, Wanderson
dc.date.accessioned 2017-11-30T11:42:33Z
dc.date.available 2017-11-30T11:42:33Z
dc.date.issued 2013-11
dc.identifier.issn 0731-7085
dc.identifier.other 1873-264X
dc.identifier.uri http://hdl.handle.net/2133/9461
dc.description In this paper the chemical imaging technique by near infrared spectroscopy was applied for characterization of drug formulations in tablets of sildenafil citrate of different sources. This work is original and has never been published because it was used the sildenafil citrate, including in the commercial one called "Viagra". In the first stage of the study, a chemometric method based on multivariate curve resolution was properly chosen for the development of the distribution map of concentrations of the active ingredient in tablets. In the second step, the normalized histograms of images from active ingredient were classified by hierarchical cluster analysis. Finally it was possible to recognize the patterns of homogeneity of images in sildenafil citrate tablet. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs. es
dc.description.sponsorship Fapesp es
dc.description.sponsorship CNPq es
dc.description.sponsorship Universidade Estadual de Campinas. Instituto de Química es
dc.format application/pdf
dc.language.iso eng es
dc.publisher Journal of Pharmaceutical and Biomedical Analysis es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/2.5/ar/ *
dc.subject Sildenafil citrate es
dc.subject Chemical imaging es
dc.subject Near infrared spectroscopy es
dc.subject Multivariate curve resolution es
dc.subject Classification es
dc.subject Recognize the patterns es
dc.title Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools es
dc.rights.holder Elsevier es
dc.rights.holder Sabin, Guilherme P. es
dc.rights.holder Lozano, Valeria A. es
dc.rights.holder Rocha, Werickson F. C. es
dc.rights.holder Romão, Wanderson es
dc.rights.holder Ortiz, Rafael S. es
dc.rights.holder Poppi, Ronei J es
dc.relation.publisherversion https://doi.org/10.1016/j.jpba.2013.07.036 es
dc.relation.publisherversion http://www.sciencedirect.com/science/article/pii/S0731708513003427?via%3Dihub es


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